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Plankton's cousin, Clem, is visiting Bikini Bottom for a vacation. After finishing the game, SpongeBob SquarePants: Creature from the Krusty Krab, Clem reflects a diabolical idea. Clem diagrams a plan to turn all the Bikini Bottomites into cold, calculating, depraved, bloodthirsty killers, who prey on other Bottomites. With the help of Plankton, Clem creates a medical injection virus that will obliterate brain functions and mutate body cells. The fate of the Pacific Ocean then lies in SpongeBob, Patrick, Sandy, and Mr. Krabs hands.
- SpongeBob SquarePants
- Patrick Star
- Sandy Cheeks
- Danny Phantom
- Eugene Harold Krabs
- Sheldon James Plankton
- Gary the Snail
- Friend (No Name)
- Squidward Tentacles
- Bikini Bottomites
- Margaret SquarePants
- Harold SquarePants
- News Man
- Brich Burcons
- Mrs. Puff
- Larry the Lobster
- Bubble Bass
- Mermaid Man and Barnacle Boy
- Jelly Spotters
- Bikini Bottom Police Department [some officers are seen as zombies, but only in cutscenes.]
- Fred Rechid
- Strong and Small Zombie Fish
- Blue, Green, Big, and Small Jellyfish
- Buff Fish
- Tuff Snails
- Fish Robots
- Fish Ghost
- Cave Fish
- Fire Fish
- Ice Fish
- Robot Strong Fish
- Dark Starfish
- Robots of Doom
- Big Nasty Foot
- Training World
- Conch Street
- Krusty Krab
- Sandy's Treedome
- Rock Bottom
- Flying Duchman's Ship
- Chum Bucket (Final world)
- Jellyfish Field's (Bonus world)
- ChumBucket Hand
- Patrick (Because you made him mad.)
- Squidward (Because he dose not wan't spongebob in his house)
- King jellyfish (Battle 1)
- Sandy's Robots
- Mean fish
- Flying Duchman
- King jellyfish (Battle 2) (Bonus mini boss.)
- Bigest Zombie fish
- Patrick bot
- Golden ell
- Spongebob Stellpants (Battle 1)
- Sandy robot
- Manray & Dirty bubble
- Bigest Flying Duchman
- Spongebot Stellpants (Battle 2) (Final boss)
- Robot jellyfish (Bouns boss!)
- Pie Used to heal the player when injured.
- Cash Used to buy essential weapons, foods, and all overall items.
- Toys Better known as Gadgets, they simply distract zombie foes.
- Clouds Used as a solid platform; the player can tiptoe on clouds only. Walking or running will result in the player seeping through the cloud and falling.
- Ghost in a Bottle Can be used against other ghosts or zombies.
- Laser Pants Can only be used when playing as Patrick.
- Goo An icky substance that can be used to trap zombies or locate ghosts.
- Invisible Spray Can be used to sneak through and past enemies. When touched by water, the spray will not work.
- Bombs Can be used to cause destruction against zombies, not ghosts.
- Keys Used to access "secret" areas.
- Forever Glue Will trap zombies and robots forever.
- Clams When released, clams will lunge and start biting opponents.
- Pearls Form of cash.
- Diamonds Form of cash.
- Gold Form of cash.
- Silver Form of cash.
- Magic The most harmful weapon. Major enemies can use black magic against the player, while you can use white magic.
- Hats Used as accessories and disguises.
- Knockout Ray Knocks out zombies and ghost. Takes 30 shots to knockout robots.
- Glasses Used as accessories and disguises. Includes Goofy Glasses and Silver Glasses (rare).
- Golden Clams Triple damage than the original Clams. Is extremely rare.
- Golden Teeth When this accessory/weapon is put on, the player can bite through enemies, with triple amount of damage. Is extremely rare.
- Molecular Separator Ray Can separate the molecules of zombies, turning them back into fish.
- Net Gun Will trap zombies only.
- Anchor Arms Can be used to beat up zombies, ghosts, robots, and major enemies to pulp.
- Candy Glove Can be used to heal the player instantly.
- Super jump
- Super sponge
- Metal power
- Strong power
- Fast crab
- Flying power
- Ultra Fry cook
- Bubble butt
- Ice power
- Fire power
- Ultra power
- 1 UP
- Crabby patty
- Max Crabby patty
- 1 Up patty