In the series premiere episode, the trio try to make a lasting impression on the citizens of Illinois by thwarting a bank robbery. However, when they discover that the situation is already being handled by Testosterone Man, the trio find themselves attempting to thwart his plan as well as the robbery/In one of their daily attempts to thwart a criminal, the trio inadvertently bump into a teenage girl recording footage of the city, and accidentally break her camera. As they apologize to the girl, they offer their help in recreating the footage she lost, which, per the norm, causes mass destruction and chaos, though they begin to form a bond with her as she tells details of her past whilst they recreate footage.
TBA/Catnip discovers that one of the most famous villains within Illinois, John Doe, who vanished over 20 years ago, is now living amongst the regular citizens of the city, has a wife and three children and is seemingly a reformed man who has no more villainous intent. Deeply suspicious of this, Catnip invites the heroes and villains of Illinois to a "wholesome family dinner", and drags Doe along for the ride in an attempt to expose him.
Arch-Nemesis Man successfully constructs a doomsday device, capable of bringing pure destruction to the Earth. However, when he discovers that other villains have built one of their own, he seeks to sabotage them so he can be the true harbinger of Earth's destruction/TBA
Feeling that that the team needs an iconic symbol in order to become popular and well-liked, Catnip tells Squirmer to design super-powered suits for them to wear. Once he does, however, a villain steals one of them and begins to mass-produce them for everyone in the city to wear, causing destruction and anarchy/TBA
The trio accientally encounter a former superhero by the name of Hugh Jass, who lives in an isolated cave outside of town. Wanting to get back into the crime-fighting business, he convinces the trio to retrieve an item that will restore his powers: the Declaration of Independence/After a string of bad ocurrences begin happening to Diane, Catnip theorizies that "fate hates her for her many sins" and convinces her that crime-fighting is the only way to reverse it
Mayor T, tired of the chaos and anarchy caused by heroes' bitter hatred and rivalry of eachother, officially declares a restraining order on them. Now that every hero is separated, this forces the gang to split up from eachother, which oddly causes even more chaos in their crime fighting crusade/
Everyone in Illinois becomes ill with a stomach virus, which is then revaled to later on turn citizens into destruction-craving maniacs. Before they meet the same fate, the trio team up with Squirmer in order to find a cure for it/The trio begin their daily routine of fighting crime, only to find that every hero and villain has taken a 7-day vacation. While this pleases Fred and Cotton, Catnip still has the thirst for crime-fighting, and causes general panic and chaos in order quench his thirst.
As the heroes of Illinois begin driving in technologically advanced vehicles and overall stopping crimes faster, the trio ask Squirmer to develop a car for them. When the car is built and the trio begin to use it, however, they become addicted to speed and adrenaline, which horribly damages Illinois/TBA
A mysterious entity begins attacking the dreams of Illinois citizens, including heroes and villains. Per the norm, the trio attempt to solve this issue, only to discover that the entity is coming from Cotton's own mind/Catnip discovers that his trademark belt, which he assumed was "fashionable but useless", is transmitting energy into him, which in turn is giving him various super powers. Soon enough, he becomes corrupt with power and turns away from the heroic life he once fought for.
Feeling that America is practically overrun with superheroes at this point, Catnip believes that they will have a more successful crime-fighting career in a different country, before finally settling on his homeland of Japan. After entering the country, however, they are hit hard with culture shock as they are forced to fight kaijus, large piloted robots, and tentacle monsters/
A reality-warping villain named Seinfeld loses his trademark magical staff in a scuffle between the trio. While experimenting with it, they discover that they can use it to chanage reality to their liking. While messing with the staff, however, they end up losing it in the new reality they have created/
The trio awaken trapped in a dirty, run-down building which gives the appearance of a game show. The trap is revealed to be set up the notorious Harvey Steve, a deranged villain-wannabe who has an obsession with game shows and has been stalking various heroes for months. He tells the trio that in order to escape, they must participate in a live event where they must answer various questions about the heroes that populate the city/After discovering that Illinois no longer has a police force due to the activity of superheroes, the President issues an outright ban on them and forces Mayor T to start up a police force. Still seeking the thrill of crime-fighting, the trio disregard the new law and continue to fight crime, but end up becoming involved in a complicated situation between the police, a robbery, and an army of demons.
As a mysterious alien entity begins destroying large cities across the globe, the heroes of Illinois are relunctantly forced to drop their working-alone routine and join a team consisting of every other hero in town due to government meddling. As expected, every hero in town fails to cooperate with eachother, which infuriates the alien entity, who demands that they pose as an actual threat.
The citizens of Illinois set up an award ceremony for the various superheroes of the city, wanting to pay tribute to them and everything they do. At the ceremony, however, various heroes begin vanishing one by one with no trace, though nobody seems to notice except for the Epic Animals themselves. The trio investigate the ceremony and attempt to discover the reasoning behind this, but soon learn that the disappearances are being caused by a rouge hero, feeling rejected for not being invited.
Through unforeseen circumstances, Fred is transported into the mindscape of of the city's most powerful villains, Bite Noire. While Catnip and Cotton team up with Squirmer in an attempt to get him out, Fred tries to use this opportunity to become a "conscious" for the villain, hoping to lead him out of his villainous lifestyle.
A world famous critic reviews The Epic Animals and gives it a bad review. This causes people to stop watching the show and merchandise sales to be at an all-time low. Kingson ends up with $1 and one animator, a fourteen year-old intern, to animate the show. After the animation and budget becomes terrible, Fred, Cotton and Catnip, all now voiced by the intern, must find a way to make some more money to get the series back up to standards before they die of cancellation disease
The villains of Illinois become irritated by a newcomer villain known simply as Dahl, an annoying attention-seeker who never stops talking about himself and generally cramps the villain's threatening appearance. Desparate and out of options, the villains band together in an attempt to kick him out of Illinois/Fred awakens one day to find that everyone and everything in town has suddenly changed. Heroes are villains, villains are heroes and Mr. Narrator actually finds himself enjoying the show. He soon discovers he is trapped in an alternate universe, and that an opposite version of himself is roaming the streets in his own dimension.
An unknown force nicknamed "Bowdlerization", angered that Mr. Narrator is narrating a "revolting and despicable burning garbage pile", removes him from the show and attempts to make it more family-friendly. This angers everyone in Illinois, prompting Squirmer to create a device that allows people to travel between their world and the "studio world" where the narrators reside. Using the device, the trio enter the studio world in an attempt to find the old narrator and return the essence of the show.